Recombinant Cynomolgus Inducible T-cell Costimulator is produced by our Mammalian expression system and the target gene encoding Gly20-Lys140 is expressed with a Fc tag at the C-terminus. Bon Opus Cat. #CW09

Recombinant Cynomolgus ICOS/AILIM/CD278 (C-Fc)

Name: Recombinant Cynomolgus ICOS/AILIM/CD278 (C-Fc)
SKU: CW09-10ug

SKU: CW09-10ug

$100.00

Quantity

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Shipping Information

$48 Standard Overnight flat rate for products shipped in room temperature within the United States.

Additional $27 Ice Packs shipment fee is required for liquid proteins.

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Certificate of Analysis

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Endotoxin

Less than 0.1 ng/ug (1 IEU/ug) as determined by LAL test.

Accession Number

H9Z062

Species

Cynomolgus

Expression System

Human Cells

Target Sequence

Gly20-Lys140

C-Fc

Formulation

Lyophilized from a 0.2 um filtered solution of PBS,pH7.4.

Packaging

Ambient

Background

Inducible T-cell costimulator, also known as activation-inducible lymphocyte immunomediatory molecule, CD278, AILIM, CVID1 and ICOS, belongs to the CD28 and CTLA4 cell surface receptor family.. ICOS contains one Ig-like V-type domain and exsits as a homodimer with disulfide-linked. ICOS is highly expressed on tonsillar T-cellsand can be induced by PMA and ionomycin, ICOS plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation. Defects in ICOS are the cause of immunodeficiency common variable type 1, which is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antige.