Recombinant Cynomolgus Cytotoxic T-lymphocyte associated protein 4 is produced by our Mammalian expression system and the target gene encoding Ala37-Ser160 is expressed with a Fc tag at the C-terminus.

Recombinant Cynomolgus CTLA-4 (C-Fc)

Name: Recombinant Cynomolgus CTLA-4 (C-Fc)
SKU: CA80-10ug

SKU: CA80-10ug

$53.00

Quantity

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Shipping Information

$48 Standard Overnight flat rate for products shipped in room temperature within the United States.

Additional $27 Ice Packs shipment fee is required for liquid proteins.

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Certificate of Analysis

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Endotoxin

Less than 0.1 ng/ug (1 EU/ug) as determined by LAL test.

Accession Number

G7PL88

Species

Cynomolgus

Expression System

Human Cells

Target Sequence

Ala37-Ser160

C-Fc

Formulation

Lyophilized from a 0.2 um filtered solution of 50 mM Tris-HCl, 100 mM Glycine, pH7.5.

Packaging

Ambient

Background

Cytotoxic Tlymphocyte 4(CTLA-4,CD152), is a type I transmembrane T cell inhibitory molecule that is a member of the Ig superfamily.CD28 and CTLA-4, together with their ligands, B7-1 and B7-2, constitute one of the dominant costimulatory pathways that regulate T and B cell responses. CD28 and CTLA-4 are structurally homologous molecules that are members of the immunoglobulin (Ig) gene superfamily. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T Cells and may play an important role in their functions. Tcell activation through the Tcell receptor and CD28 leads to increased expression of CTLA4.